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There is a growing concern in the medical community about the unreliability of current coagulation analyzers in predicting bleeding or thrombotic complications, specifically in patients with coagulopathy. The major source of measurement errors is the exposure of blood samples to an artificial environment such as container walls. In addition, relatively large volumes of blood (2-3 mL) are required for coagulation analysis, which is a serious health risk for neonates and small children as well as patients with anemia.

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