Our platform is built around acoustic levitation technology that enables quantitative viscoelastic and optical measurements of a sample with high accuracy and repeatability. This non-contact technique avoids premature clotting due to surface contamination for higher reliability.
Coagulation measurements are performed without any surfaces contacting the sample, avoiding contamination and tainted results.
Small sample volume
Only one drop of blood (< 6 µL) is needed for testing. 60x less than competing solutions.
Plasma and blood assays with the ability to monitor viscoelasticity, PT, aPTT, thrombin generation and platelet function simultaneously.
Tests are completed within 10 minutes.
Patents and Publications
PCT/US2014/55559: “Apparatus, Systems & Methods for Non-Contact Rheological Measurements of Biological Materials” (approved).
PCT/US2018/014879: “Integrative Photo-Optical/Mechanical Test for Noncontact Measurement of Polymerization” (approved).
PCT/US2021/15336: “Apparatus, Systems And Methods For In Vitro Screening Of Complex Biological Fluids” (pending)
Kasireddy, Nithya, Jeremy C. Orie, and Damir B. Khismatullin. "Drop-of-sample rheometry of biological fluids by noncontact acoustic tweezing spectroscopy." Lab on a Chip 22.16 (2022): 3067-3079.
Ansari Hosseinzadeh, Vahideh, et al. "Monitoring of blood coagulation with non‐contact drop oscillation rheometry." Journal of Thrombosis and Haemostasis 17.8 (2019): 1345-1353.
Holt, R. G., Luo, D., Gruver, N., & Khismatullin, D. B. (2017). Quasi‐static acoustic tweezing thromboelastometry. Journal of Thrombosis and Haemostasis, 15(7), 1453-1462.
Ansari Hosseinzadeh, V., & Holt, R. G. (2017). Finite amplitude effects on drop levitation for material properties measurement. Journal of Applied Physics, 121(17), 174502.
Ansari Hosseinzadeh, V., Brugnara, C. & Holt, R. G. (2018). Shape oscillations of single blood drops: applications to human blood and sickle cell disease. Scientific Reports, SREP-18-14668.
Luo, D., Chelales, E. M., Beard, M. M., Kasireddy, N., & Khismatullin, D. B. (2021). Drop-of-blood acoustic tweezing technique for integrative turbidimetric and elastometric measurement of blood coagulation. Analytical and bioanalytical chemistry, 413(12), 3369-3379.